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Dr

Manousos Klados

Programme Lead
Associate Professor
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Department:

I am a mathematician with an M.Sc. in Computational Neuroscience and a PhD at the intersection of Affective, Cognitive, and Computational Neurosciences, awarded in 2014 by the School of Medicine, Aristotle University of Thessaloniki. From 2014–2016, I was a postdoctoral fellow at the Max Planck Institute for Human Cognitive and Brain Sciences (Leipzig), studying the neural correlates of personality, followed by a senior research and teaching fellowship at TU Dresden (2016–2017), focusing on cortical network development. From 2017–2020, I lectured at Aston University, UK, completing a PGCert in Higher Education and earning Fellowship of the Higher Education Academy.

I have authored 25 journal articles and 30+ conference contributions. My research covers mathematical anxiety, brain networks, affective neuroscience, and biomedical signal processing. I coordinate an EU H2020-MC-RISE project, co-lead a Knowledge Transfer Partnership, and supervise PhD and MSc students. I am a Fellow of the Institute of Mathematics and its Applications and review for international journals and funding bodies.

  • Discovering Science
  • Research Methods in Psychology
  • Introduction in Research Methods in Counseling Psychology
  • Fundamentals of Neuropsychology
  • Introduction in Research Methods in Neuropsychology
  • Research Methods in Counseling Psychology

From a neuroscientific point of view, I am interested in affective and personality neurosciences, as well as in disorders that mainly affect the connectome. Based on these I am also interested in the applied aspect of neuroscience, and more specificialy with low cost devices. Some examples are the affective and personality computing, where I am trying to classify emotions and personality types using biosignals. From a methodological perspective, my main research interests are based mostly on human connectivity, and graph theoretical modeling of human’s brain, as well as the modulation introduced in brain networks either by affective and/or cognitive stimuli or under pathological circumstances.

ORCID profile: Research, scholarship, and innovation activities

Peer – reviewed international journals

Anagnostopoulou, A., Styliadis, C., Kartsidis, P., Romanopoulou, E., Zilidou, V., Karali, C., Karagianni, M., Klados, M., Paraskevopoulos, E., Bamidis, P. D. (2020). Computerized physical and cognitive training improves the functional architecture of the brain in adults with Down Syndrome: a network science EEG study. Network Neuroscience. Advance publication. https://doi.org/10.1162/netn_a_00177

Klados, M. A., Konstantinidi, P., Dacosta-Aguayo, R., Kostaridou, V.-D., Vinciarelli, A., & Zervakis, M. (2020). Automatic Recognition of Personality Profiles Using EEG Functional Connectivity During Emotional Processing. In Brain Sciences (Vol. 10, Issue 5). https://doi.org/10.3390/brainsci10050278

Sciaraffa, N., Klados, M. A., Borghini, G., Flumeri, G. Di, Babiloni, F., & Aricò, P. (2020). Double-Step Machine Learning Based Procedure for HFOs Detection and Classification. Brain Sciences 2020, Vol. 10, Page 220, 10(4), 220. https://doi.org/10.3390/BRAINSCI10040220

Ros, T., Enriquez-Geppert, S., Zotev, V., Young, K. D., Wood, G., Whitfield-Gabrieli, S., Wan, F., Vuilleumier, P., Vialatte, F., Van De Ville, D., Todder, D., Surmeli, T., Sulzer, J. S., Strehl, U., Sterman, M. B., Steiner, N. J., Sorger, B., Soekadar, S. R., Sitaram, R., … Thibault, R. T. (2020). Consensus on the reporting and experimental design of clinical and cognitive-behavioural neurofeedback studies (CRED-nf checklist). Brain. https://doi.org/10.1093/brain/awaa009

**Baeuchl, C., Chen, H.-Y., Su, Y.-S., Hämmerer, D., Klados, M. A.*, & Li, S.-C*. (2019). Interactive effects of dopamine transporter genotype and aging on resting-state functional networks. PLOS ONE, 14(5), e0215849. https://doi.org/10.1371/journal.pone.0215849

Klados, M. A., Paraskevopoulos, E., Pandria, N., & Bamidis, P. D. (2019). The impact of math anxiety on working memory: A cortical activations and cortical functional connectivity EEG study. IEEE Access, 1–1. https://doi.org/10.1109/ACCESS.2019.2892808

Ros, T., Enriquez-Geppert, S., Zotev, V., Young, K., Wood, G., Whitfield-Gabrieli, S., … Thibault, R. T. (2019, January 23). Consensus on the reporting and experimental design of clinical and cognitive-behavioural neurofeedback studies (CRED-nf checklist). https://doi.org/10.31234/osf.io/nyx84

Pezoulas, V. C., Michalopoulos, K., Klados, M., Micheloyannis, S., Bourbakis, N., & Zervakis, M. (2018). Functional connectivity analysis of cerebellum using spatially constrained spectral clustering. IEEE Journal of Biomedical and Health Informatics, 1–1. http://doi.org/10.1109/JBHI.2018.2868918

Ilg, L., Klados, M., Alexander, N., Kirschbaum, C., & Li, S.-C. (2018). Long-term impacts of prenatal synthetic glucocorticoids exposure on functional brain correlates of cognitive monitoring in adolescence. Scientific Reports, 8(1)http://doi.org/10.1038/s41598-018-26067-3

Athanasiou, A., Klados, M. A., Pandria, N., Foroglou, N., Kavazidi, K. R., Polyzoidis, K., & Bamidis, P. D. (2017). A Systematic Review of Investigations into Functional Brain Connectivity Following Spinal Cord Injury. Frontiers in Human Neuroscience. Retrieved from https://www.frontiersin.org/article/10.3389/fnhum.2017.00517

Klados, M. A., Pandria, N., Micheloyannis, S., Margulies, D., & Bamidis, P. D. (2017). Math anxiety: Brain cortical network changes in anticipation of doing mathematics. International Journal of Psychophysiology. http://doi.org/10.1016/j.ijpsycho.2017.05.003

**Pezoulas, V., Zervakis, M., Micheloyannis, S., & Klados, M. A. (2017). Resting-state functional connectivity and network analysis of cerebellum with respect to crystallized IQ and gender. Frontiers in Human Neuroscience. Retrieved from http://journal.frontiersin.org/article/10.3389/fnhum.2017.00189

Jakobsen, E., Liem, F., Klados, M. A., Bayrak, Ş., Petrides, M., & Margulies, D. S. (2016). Automated individual-level parcellation of Broca’s region based on functional connectivity. NeuroImage. http://doi.org/10.1016/j.neuroimage.2016.09.069

Klados, M. A., & Bamidis, P. D. (2016). A semi-simulated EEG/EOG dataset for the comparison of EOG artifact rejection techniques. Data in Brief, 8, 1004–1006. http://doi.org/10.1016/j.dib.2016.06.032

Athanasiou, A., Klados, M. A., Styliadis, C., Foroglou, N., Polyzoidis, K., & Bamidis, P. D. (2016). Investigating the role of alpha and beta rhythms in functional motor networks. Neuroscience. http://doi.org/10.1016/j.neuroscience.2016.05.044

Klados, M. A., Styliadis, C., Frantzidis, C. A., Paraskevopoulos, E., & Bamidis, P. D. (2016). Beta-Band Functional Connectivity is Reorganized in Mild Cognitive Impairment after Combined Computerized Physical and Cognitive Training. Frontiers in Neuroscience, 10. http://doi.org/10.3389/fnins.2016.00055

Klados, M. A., Simos, P., Micheloyannis, S., Margulies, D., & Bamidis, P. D. (2015). ERP measures of math anxiety: how math anxiety affects working memory and mental calculation tasks? Frontiers in Behavioral Neuroscience, 9. http://doi.org/10.3389/fnbeh.2015.00282

Frantzidis, C. A., Vivas, A. B., Tsolaki, A., Klados, M. A., Tsolaki, M., & Bamidis, P. D. (2014). Functional disorganization of small-world brain networks in mild Alzheimer’s Disease and amnestic Mild Cognitive Impairment: an EEG study using Relative Wavelet Entropy (RWE). Frontiers in Aging Neuroscience, 6. http://doi.org/10.3389/fnagi.2014.00224

Klados, M. A. & Bamidis, P.D.(2014). Beyond the Clinical Use of Neurofeedback. Journal of Psychology & Clinical Psychiatry, 1(3). http://doi.org/10.15406/jpcpy.2014.01.00014

Bamidis, P. D., Vivas, A. B., Styliadis, C., Frantzidis, C., Klados, M.A., Schlee, W., … Papageorgiou, S. G. (2014). A review of physical and cognitive interventions in aging. Neuroscience & Biobehavioral Reviews, 44, 206–220. http://doi.org/10.1016/j.neubiorev.2014.03.019

Klados, M. A., Kanatsouli, K., Antoniou, I., Babiloni, F., Tsirka, V., Bamidis, P. D., & Micheloyannis, S. (2013). A Graph theoretical approach to study the organization of the cortical networks during different mathematical tasks. PloS One, 8(8), e71800. http://doi.org/10.1371/journal.pone.0071800

Athanasiou, A., Lithari, C., Kalogianni, K., Klados, M. A., & Bamidis, P. D. (2012). Source Detection and Functional Connectivity of the Sensorimotor Cortex during Actual and Imaginary Limb Movement: A Preliminary Study on the Implementation of eConnectome in Motor Imagery Protocols. Advances in Human-Computer Interaction, 2012, 1–10. http://doi.org/10.1155/2012/127627

Lithari, C., Klados, M. A., Papadelis, C., Pappas, C., Albani, M., & Bamidis, P. D. (2012). How does the metric choice affect brain functional connectivity networks? Biomedical Signal Processing and Control, 7(3), 228–236. http://doi.org/10.1016/j.bspc.2011.05.004

Lithari, C., Klados, M. A., Pappas, C., Albani, M., Kapoukranidou, D., Kovatsi, L., … Papadelis, C. L. (2012). Alcohol Affects the Brain’s Resting-State Network in Social Drinkers. PLoS ONE, 7(10).

Klados, M. A., Papadelis, C., Frantzidis, C., & Bamidis, P. (2011). Is the Artifact Rejection enhanced if the EOG signals are included in the ICA decomposition? Neuroscience Letters, 500, e50–e51. http://doi.org/10.1016/j.neulet.2011.05.216

Moridis, C., Klados, M. A., Terzis, V., Economides, A., Karlovasitou, A., Bamidis, P., & Karabatakis, V. (2011). Audiovisual stimulation to influence alpha brain oscillations: An EEG study of gender differences. Neuroscience Letters, 500, e51. http://doi.org/10.1016/j.neulet.2011.05.217

Frantzidis, C., Semertzidou, A., Ladas, A., Karagianni, M., Lithari, C., Kyrillidou, A., … Bamidis, P. (2011). Detecting neurophysiological alterations during Mild Cognitive Impairment and Dementia using wavelet-based energy computation and a Mahalanobis Distance classifier. Neuroscience Letters, 500, e53. http://doi.org/10.1016/j.neulet.2011.05.225

Klados, M. A., Papadelis, C., Braun, C., & Bamidis, P. D. (2011). REG-ICA: A hybrid methodology combining Blind Source Separation and regression techniques for the rejection of ocular artifacts. Biomedical Signal Processing and Control, 6(3), 291–300. http://doi.org/10.1016/j.bspc.2011.02.001

Frantzidis, C. A., Bratsas, C., Klados, M. A., Konstantinidis, E., Lithari, C. D., Vivas, A. B., … Bamidis, P. D. (2010). On the Classification of Emotional Biosignals Evoked While Viewing Affective Pictures: An Integrated Data-Mining-Based Approach for Healthcare Applications. IEEE Transactions on Information Technology in Biomedicine, 14(2), 309–318. http://doi.org/10.1109/TITB.2009.2038481

Lithari, C., Frantzidis, C., Klados, M. A., & Bamidis, P. D. (2010). Does arousal and valence affect ERPs and brain connectivity? A study during an emotional paradigm. International Journal of Psychophysiology, 77(3), 266–266. http://doi.org/10.1016/j.ijpsycho.2010.06.101

Lithari, C., Frantzidis, C. A., Papadelis, C., Vivas, A. B., Klados, M. A., Kourtidou-Papadeli, C., … Bamidis, P. D. (2010). Are females more responsive to emotional stimuli? A neurophysiological study across arousal and valence dimensions. Brain Topography, 23(1), 27–40. http://doi.org/10.1007/s10548-009-0130-5

Klados, M. A., Frantzidis, C., Vivas, A. B., Papadelis, C., Lithari, C., Pappas, C., & Bamidis, P. D. (2009). A Framework Combining Delta Event-Related Oscillations (EROs) and Synchronisation Effects (ERD/ERS) to Study Emotional Processing. Computational Intelligence and Neuroscience, 2009, 1–16. http://doi.org/10.1155/2009/549419

Presentations in international coferences with published proceedings

Giannakaki, K., Giannakakis, G., Vorgia, P., Klados, M., & Zervakis, M. (2019). Automatic Absence Seizure Detection Evaluating Matching Pursuit Features of EEG Signals. 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering (BIBE), 886–889. https://doi.org/10.1109/BIBE.2019.00165

Klados, G. A., Zervakis, M., Dacosta-Aguayo, R., Fratini, A., & Klados, M. A. (2019). Towards a Novel Way to Predict Deficits After a Brain Lesion: A Stroke Example. 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering (BIBE), 737–741. https://doi.org/10.1109/BIBE.2019.00138

Fenech, M., Seri, S., & Klados, M. (2019). High-Frequency Oscillations in Epilepsy: A Short Review. 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering (BIBE), 882–885. https://doi.org/10.1109/BIBE.2019.00164

Pezoulas, V. C., Athanasiou, A., Nolte, G., Zervakis, M., Fratini, A., Fotiadis, D. I., & Klados, M. A. (2018). FCLAB: An EEGLAB module for performing functional connectivity analysis on single-subject EEG data. In 2018 IEEE EMBS International Conference on Biomedical & Health Informatics (BHI) (pp. 96–99). IEEE. https://doi.org/10.1109/BHI.2018.8333378

Klados, M. A., Pandria, N., Athanasiou, A., & Bamidis, P. D. (2017). An Automatic EEG Based System for the Recognition of Math Anxiety. In 2017 IEEE 30th International Symposium on Computer-Based Medical Systems (CBMS) (pp. 409–412). IEEE. http://doi.org/10.1109/CBMS.2017.107

Dacosta-Aguayo, R., Stephan-Otto, C., Auer, T., Clemente, I., Davalos, A., Bargallo, N., … Klados, M. A. (2017). Predicting Cognitive Recovery of Stroke Patients from the Structural MRI Connectome Using a Naïve Bayesian Tree Classifier. In 2017 IEEE 30th International Symposium on Computer-Based Medical Systems (CBMS) (pp. 413–418). IEEE. http://doi.org/10.1109/CBMS.2017.106

Klados, M.A., Lauckner, M., Jackobsen, E., & Daniel, M. (2016). Characterizing the Primary Spectrum of Personality and Brain Connectivity. In 22nd Annual Meeting of the Organization for Human Brain Mapping.

Pezoulas, V., Zervakis, M., Micheloyannis, S., & Klados, M. A. (2016). Investigating the correlation between crystallized IQ and network metrics in cerebellum using resting-state fMRI. Frontiers in Human Neuroscience, 10. http://doi.org/10.3389/conf.fnhum.2016.220.00013

Klados, M. A. (2016). Human Connectome as a big-data problem: New approaches for analysis and visualization. Frontiers in Human Neuroscience, 10. http://doi.org/10.3389/conf.fnhum.2016.220.00012

Athanasiou, A., Klados, M. A., Astaras, A., Foroglou, N., Magras, I., & Bamidis, P. D. (2016). State of the Art and Future Prospects of Nanotechnologies in the Field of Brain-Computer Interfaces. In XIV Mediterranean Conference on Medical and Biological Engineering and Computing (pp. 456–460). Springer. http://doi.org/10.1007/978-3-319-32703-7_89

Athanasiou, A., Klados, M. A., Foroglou, N., Klados, K. R., Polyzoidis, K., & Barnidis, P. D. (2016). Reorganization of brain networks after spinal cord injury: a qualitative synthesis of the literature. Frontiers in Human Neuroscience, 10. http://doi.org/10.3389/conf.fnhum.2016.220.00036

Bayrak, Ş., Margulies, D., Bamidis, P., & Klados, M. A. (2016). Mathematical Anxiety influences the cortical connectivity profiles in lower alpha band during working memory tasks. Frontiers in Human Neuroscience, 10. http://doi.org/10.3389/conf.fnhum.2016.220.00001

Jakobsen, E., Klados, M.A., Zelmer, J., Goulas, A., & Margulies, D. S. (2015). Automated individual-level parcellation of Broca’s region based on resting-state functional connectivity. In 21st Annual Meeting of the Organization for Human Brain Mapping (OHBM).

Klados, M. A., Styliadis, C., & Bamidis, P. D. (2014). A Short Review on Emotional Recognition Based on Biosignal Pattern Analysis. In XIII Mediterranean Conference on Medical and Biological Engineering and Computing (pp. 787–790). http://doi.org/10.1007/978-3-319-00846-2_195

Bamparopoulos, G., Klados, M. A., Papathanasiou, N., Antoniou, I., Micheloyannis, S., & Bamidis, P. D. (2014). Studying Functional Brain Networks to Understand Mathematical Thinking: A Graph-Theoretical Approach. In L. M. Roa Romero (Ed.), XIII Mediterranean Conference on Medical and Biological Engineering and Computing (Vol. 41, pp. 783–786). Springer International Publishing. http://doi.org/10.1007/978-3-319-00846-2_194

Klados, M. A., Nikolaidou, M., Konstantinidis, E., Chifari, A., & Bamidis, P. D. (2013). A short review of computerized monitoring systems for ADHD. In Proceedings of the 26th IEEE International Symposium on Computer-Based Medical Systems (pp. 556–557). IEEE. http://doi.org/10.1109/CBMS.2013.6627875

Klados, M. A., Lithari, C., Antoniou, I., Semertzidou, A., Bratsas, C., Micheloyannis, S., & Bamidis, P. D. (2012). Towards a graph theoretical approach to study gender lateralization effect in mathematical thinking. In 2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) (pp. 666–670). IEEE. http://doi.org/10.1109/BIBE.2012.6399746

Frantzidis, C. A., Diamantoudi, M. D., Grigoriadou, E., Semertzidou, A., Billis, A., Konstantinidis, E., … Bamidis, P. D. (2012). A Mahalanobis Distance Based Approach towards the Reliable Detection of Geriatric Depression Symptoms Co-existing with Cognitive Decline. In L. Iliadis, I. Maglogiannis, H. Papadopoulos, K. Karatzas, & S. Sioutas (Eds.), Artificial Intelligence Applications and Innovations SE – 2 (Vol. 382, pp. 16–25). Springer Berlin Heidelberg. http://doi.org/10.1007/978-3-642-33412-2_2

Artikis, A., Bamidis, P. D., Billis, A., Bratsas, C., Frantzidis, C., Karkaletsis, V., … others. (2012). Supporting tele-health and AI-based clinical decision making with sensor data fusion and semantic interpretation: The USEFIL case study. International Workshop on Artificial Intelligence and NetMedicine, 21.

Klados, M. A., Bratsas, C., Frantzidis, C., Papadelis, C. L., & Bamidis, P. D. (2010). A Kurtosis-Based Automatic System Using Naïve Bayesian Classifier to Identify ICA Components Contaminated by EOG or ECG Artifacts. In XII Mediterranean Conference on Medical and Biological Engineering and Computing (pp. 49–52). http://doi.org/10.1007/978-3-642-13039-7_13

Lithari, C., Klados, M. A., & Bamidis, P. D. (2010). Graph Analysis on Functional Connectivity Networks during an Emotional Paradigm. In XII Mediterranean Conference on Medical and Biological Engineering and Computing (pp. 115–118). Springer. http://doi.org/10.1007/978-3-642-13039-7_29

Moridis, C. N., Klados, M. A., Terzis, V., Economides, A. A., Karabatakis, V. E., Karlovasitou, A., & Bamidis, P. D. (2010). Affective Learning: Empathetic Embodied Conversational Agents to Modulate Brain Oscillations. In XII Mediterranean Conference on Medical and Biological Engineering and Computing (pp. 675–678). http://doi.org/10.1007/978-3-642-13039-7_170

Komnidis, A., Konstantinidis, E., Stylianou, I., Klados, M. A., Kalfas, A., & Bamidis, P. D. (2010). A Modular Architecture of a Computer-Operated Olfactometer for Universal Use. In XII Mediterranean Conference on Medical and Biological Engineering and Computing (pp. 280–283). http://doi.org/10.1007/978-3-642-13039-7_70

Moridis, C. N., Klados, M. A., Kokkinakis, I. A., Terzis, V., Economides, A. A., Karlovasitou, A., … Karabatakis, V. E. (2010). The impact of audio-visual stimulation on alpha brain oscillations: An EEG study. In Proceedings of the 10th IEEE International Conference on Information Technology and Applications in Biomedicine (pp. 1–4). IEEE. http://doi.org/10.1109/ITAB.2010.5687651

Frantzidis, C. A., Lithari, C. D., Klados, M. A., Pappas, C., & Bamidis, P. D. (2010). Synchronization analysis of short EEG data through time-evolving relative wavelet entropy and IAPS affective visual stimuli. In Proceedings of the 10th IEEE International Conference on Information Technology and Applications in Biomedicine (pp. 1–4). IEEE. http://doi.org/10.1109/ITAB.2010.5687646

Peranonti, E. G., Klados, M. A., Papadelis, C. L., Kontotasiou, D. G., Kourtidou-Papadeli, C., & Bamidis, P. D. (2010). Can the EEG Indicate the FiO2 Flow of a Mechanical Ventilator in ICU Patients with Respiratory Failure? In XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010 (pp. 827–830). Springer. http://doi.org/10.1007/978-3-642-13039-7_209

Lithari, C., Frantzidis, C. A. A., Papadelis, C., Klados, M. A., Pappas, C., & Bamidis, P. D. D. (2010). Small-world properties of brain Functional Connectivity Networks are affected by emotional stimuli. In Proceedings of the 10th IEEE International Conference on Information Technology and Applications in Biomedicine (pp. 1–4). IEEE. http://doi.org/10.1109/ITAB.2010.5687815

Bratsas, C., Frantzidis, C. A., Klados, M.A., Papadelis, C., Pappas, C., & Bamidis, P. D. (2009). Towards a semantic framework for an integrative description of neuroscience patterns and studies: a case for emotion-related data. Studies in Health Technology and Informatics, 150, 322–6. http://doi.org/10.3233/978-1-60750-044-5-322

Klados, M. A., Papadelis, C., Lithari, C. D., & Bamidis, P. D. (2009). The Removal Of Ocular Artifacts From EEG Signals: A Comparison of Performances For Different Methods. In 4th European Conference of the International Federation for Medical and Biological Engineering (pp. 1259–1263). http://doi.org/10.1007/978-3-540-89208-3_300

Bamidis, P. D., Frantzidis, C. A., Konstantinidis, E. I., Luneski, A., Lithari, C., Klados, M. A., … Pappas, C. (2009). An Integrated Approach to Emotion Recognition for Advanced Emotional Intelligence. In 13th International Conference of HCI International (pp. 565–574). http://doi.org/10.1007/978-3-642-02580-8_62

Klados, M. A., Papadelis, C. L., & Bamidis, P. D. (2009). REG-ICA: A new hybrid method for EOG Artifact Rejection. In 2009 9th International Conference on Information Technology and Applications in Biomedicine (pp. 1–4). IEEE. http://doi.org/10.1109/ITAB.2009.5394295

Academic qualifications

  • PhD in Medicine (focus on Affective and Cognitive Neuroscience), Aristotle University of Thessaloniki, Greece
  • MSc in Medical Informatics (focus on Computational Neuroscience), Aristotle University of Thessaloniki, Greece
  • BSc in Mathematics, Aristotle University of Thessaloniki, Greece

Contact

Email: mklados@yorkeuropecampus.eu
Phone: 2310 692020
Office location: Galini Campus

Teaching info

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